poly(ADP-ribose) polymerase
- poly(ADP-ribose) polymerase
-
(= PARP)
(EC 2.4.2.30) An abundant nuclear
protein activated by
DNA nicks and important in
DNA repair. PolyADP ribosylation, brought about by ADP-ribosyl
protein ligase, is
a post-transcriptional modification of proteins and
p53 is one of the proteins that can be modified in this way.
PARP knockout mice show defects in
fibroblast proliferation and impaired capacity to handle radiation-induced damage. One of the earliest proteins cleaved by caspase 3 in apoptosis.
Dictionary of molecular biology.
2004.
Look at other dictionaries:
Poly(ADP-ribose)-Polymerase 1 — Poly (ADP ribose) polymerase 1 Struktur von PARP1 nach PDB … Deutsch Wikipedia
Poly ADP ribose polymerase — For the sound, see Parp (onomatopoeic). ADP ribose … Wikipedia
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NAD(P)(+)—protein-arginine ADP-ribosyltransferase — NAD(P)+ protein arginine ADP ribosyltransferase Identifiers EC number 2.4.2.31 CAS number 81457 93 4 … Wikipedia
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Adenosine diphosphate ribose — Chembox new ImageFile=Adenosine diphosphate ribose.svg ImageFile2=Adenosine diphosphate ribose 3D.png ImageSize=250px ImageSize2=250px IUPACName= OtherNames=ADP ribose Section1= Chembox Identifiers CASNo=20762 30 5 PubChem=192 SMILES=… … Wikipedia
PARP1 — Poly (ADP ribose) polymerase 1 PDB rendering based on 1uk0 … Wikipedia
PARP2 — Poly (ADP ribose) polymerase 2 PDB rendering based on 1gs0 … Wikipedia
PARP4 — Poly (ADP ribose) polymerase family, member 4 Identifiers Symbols PARP4; ADPRTL1; PARP 4; PARPL; PH5P; VAULT3; VPARP; VWA5C; p193 External IDs … Wikipedia
PARP10 — Poly (ADP ribose) polymerase family, member 10 PDB rendering based on 2dhx … Wikipedia
